Michele Kelemen

Hillary Clinton is preparing to leave the Obama administration after four years as secretary of state, earning generally high marks and fueling all kinds of speculation about what she wants to do next.

Her boss, President Obama, has paid tribute to her, calling her "tireless and extraordinary," though illness and a concussion have kept her out of public view for the past two weeks.

"More than 400 travel days, nearly 1 million miles," President Obama proclaimed at a diplomatic reception recently. "These are not frequent flier miles. She doesn't get discounts."

Long before President Obama nominated John Kerry as the country's top diplomat, the Massachusetts senator was seen as a secretary of state in waiting.

He has been chairman of the Senate Foreign Relations Committee and has frequently jetted off to Afghanistan and Pakistan whenever the Obama administration needed him.

Under fire from Republicans, U.S. Ambassador to the United Nations Susan Rice took herself out of the running to become the next secretary of State. Rice told President Obama that if she were to be nominated, the confirmation process would be "lengthy, disruptive and costly."

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DAVID GREENE, HOST:

As Syrian fighting intensifies in Syria, diplomatic efforts are also heating up.

U.S. Secretary of State Hillary Clinton, Russian Foreign Minister Sergei Lavrov and the main international envoy to Syria were all in Dublin for an international gathering Thursday. The meeting came as Syria's opposition tries to get better organized to offer a real alternative to President Bashar Assad's regime.